Enzymatic Transformation of Betalactam Antibiotics. Trends of Development and Approaches to Practical Implementation
نویسندگان
چکیده
The general approaches to enzymatic synthesis of semisynthetic betalactam antibiotics were developed. The principal scheme includes the enzymatic transformation of natural antibiotics to key amino acids and following their acylation to produce the semisynthetic betalactams. Ten various biocatalysts are enough for production of all semisynthetic betalactams according to the scheme. The physico-chemical approaches to development of biocatalytic processes of betalactam antibiotic transformation and synthesis as well to design of biocatalysts of these processes are discussed.
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